Forbes has compiled its first-ever list of the nation’s top 50 most successful, self-made women as measured by their net worths.

The exclusive freshman class includes entrepreneurs, CEOs, entertainers, designers and even an author, Forbes reports. Some of the list members are extremely well-known, starting with the likes of Oprah Winfrey and Facebook’s Sheryl Sandberg. Others, like Kathy Fields and Katie Rodan, dermatologists who created acne treatment Proactiv and now have another skin care company, aren’t quite household names yet but may be on their way.

Elizabeth Holmes, who dropped out of Stanford to launch blood testing firm Theranos in 2003, tops the list with a net worth of $4.5 billion.

To be eligible for the list, women had to have substantially made their own fortunes and be U.S. citizens or permanent residents. In cases where they started businesses with, and still share with, their husbands, Forbes assigned them half of that combined wealth.

See the full list at Forbes.com.